General Information

  • ID:  hor002908
  • Uniprot ID:  P42984
  • Protein name:  Myotropic neuropeptide 1
  • Gene name:  NA
  • Organism:  Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora decemlineata)
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Leptinotarsa (genus), Doryphorini (tribe), Chrysomelinae (subfamily), Chrysomelidae (family), Chrysomeloidea (superfamily), Cucujiformia (infraorder), Polyphaga (suborder), Coleoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  AYNGPLA
  • Length:  7(1-7)
  • Propeptide:  AYNGPLA
  • Signal peptide:  NA
  • Modification:  T7 Alanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Stimulates the contractions of the oviduct
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002908_AF2.pdbhor002908_ESM.pdb

Physical Information

Mass: 81199 Formula: C32H48N8O10
Absent amino acids: CDEFHIKMQRSTVW Common amino acids: A
pI: 6.09 Basic residues: 0
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: 8.57 Boman Index: 270
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 84.29
Instability Index: -1290 Extinction Coefficient cystines: 1490
Absorbance 280nm: 248.33

Literature

  • PubMed ID:  7651886
  • Title:  Identification, characterization, and immunological localization of a novel myotropic neuropeptide in the Colorado potato beetle, Leptinotarsa decemlineata.